PT inhibits HGG cell migration.

<p>(A) U251vIII cells were allowed to migrate in Transwells for 18 h. PT was added to both Transwell chambers at the indicated concentrations. Migration is shown relative to untreated controls (mean ± SEM; n = 3; ***<i>p</i><0.001). (B) Migration was performed as described in panel A with U87vIII cells (mean ± SEM; n = 3; ***<i>p</i><0.001). (C) Migration was performed as described in panel A with Ink4a/Arf^-/-vIII astrocytes (mean ± SEM; n = 3; ***<i>p</i><0.001). (D) Migration was performed as described in panel A with mouse cortical astrocytes (mean ± SEM; n = 2 with three internal replicates; ***<i>p</i><0.001).