Effect of <i>in vivo</i> prophylactic fingolimod on the anxiety-like behaviour in EAE mice.

<p>Fingolimod untreated (white circle, n = 15 mice) control mice; fingolimod treated (white triangle, n = 15 mice) control mice; Fingolimod untreated (black circle, n = 16 mice) EAE mice; Fingolimod treated (grey triangle, n = 16 mice) EAE mice at 7 and 18 d.p.i. were monitored for anxiety-therapeutic behaviour that was quantified in the light dark box as total time spent into the lighted compartment [time in the light (sec), <b>A</b>] and as number of crossings from the lighted to the dark side of the box [crossings (n), <b>B</b>]. Anxiety was also quantified as time spent in periphery (thigmotaxis) in the open field (<b>C</b>). Data represent the media ± SEM. * <i>p</i> < 0.05 at least versus fingolimod-treated EAE mice at 7 d.p.i; ° <i>p</i> < 0.05 at least versus untreated EAE mice at 18 d.p.i.