Boc2-treatment reduces anxiety-like behaviour in C57BL/6 mice.

<p>The bar graphs in <b>A</b> show the total number of squares crossed, rears and centre crossings of Boc2-treated mice compared to PBS vehicle-treated during a 5-minute trial in the open field test. The bar graph in B shows the total time (seconds) spent in the lit area and the latency (seconds) to first cross to the dark chamber of Boc2-treated mice compared to PBS vehicle-treated mice during a 5-minute trial. Values are expressed as median ± S.E.M. and representative of four different experiments involving 6 mice per group. * <i>P</i><0.05 and ** <i>P</i><0.01 indicate significant values compared to PBS-vehicle treated mice (Mann–Whitney <i>U</i>-test).