Fisetin reduces an experimental index of anxiety in Akita mice.

<p>Male Akita mice were fed control diet or fisetin (0.05%) diet for 18 weeks beginning at 6 weeks of age. Locomotor activity was measured in the open field test. Decreased locomotor activity is an indicator of elevated anxiety that is characteristic of diabetics in poor glycemic control. Fisetin restored (A) distance traveled and (B) time ambulatory to nearly control levels. All data are mean ± SD of <i>n</i> = 5–7/group. *(<i>p</i><0.05) and **(<i>p</i><0.01) indicate significantly different from wild type or Akita alone as determined by ANOVA followed by Tukey's post test.