SAMP mice are more susceptible to tumorigenesis after AOM/DSS administration.

<p>High resolution endoscopic images of distal colons following AOM/DSS administration revealed remarkable tumorigenesis in SAMP mice (A), as both endoscopic scores and tumor numbers are shown to be increased compared to AKRs. ** <i>P</i> < 0.01; n = 12, ** <i>P</i> < 0.01; n = 6, respectively. Representative photomicrographs of colon sections stained with H&E showed that SAMP mice develop tubular adenoma with high-grade dysplasia, while AKR only developed low-grade dysplasia (B). Representative photomicrographs of colon biopsy stained with H&E showed that SAMP mice develop intramucosal carcinoma (D). Histological sections treated with BrdU antibody showed that a higher number of cells are actively replicating their DNA (brown staining) in colonic sections from SAMP vs. AKR mice (C). **** <i>P</i> = 0.0001. Stereomicroscopic images of colonic tissues showed that SAMP mice had a significantly higher percentage of tumor burden than AKRs (E). ** <i>P</i> = 0.0023.