Reduced incidence and size of colorectal adenomas in DSS-treated APCmin lacking MCH.

<p>To induce colitis, six week old WT (n = 24) and MCH-KO (n = 32) mice, both of the APCmin background, were treated with 2% DSS in their drinking water for 7 days. At 11 weeks of age, mice were evaluated for colonic tumor development. (A) Changes in body weight over time in mice treated with DSS are expressed as % of their body weight at 6 weeks of age. (B) Representative pictures of tumor development patterns in the colon of WT and MCH-KO mice. Striking differences in tumor development between the two genotypes were noted in the rectal area. (C) Not only a lower percentage of MCH KO mice developed colorectal lesions, but (D) also the size of these lesions was smaller in the MCH-KO mice. (E) Percentage of adenoma-free area in the colon of WT and MCH-KO mice. *p<0.05; **p<0.01; ****p<0.001.