Susceptibility of Casp6 deficient mice to AOM/DSS treatment.

<p>(A) Percent weight change measured weekly during AOM-DSS treatment. The black boxes represent the period for DSS treatment. Inset: Casp6 mRNA was assessed by RT-PCR with primers amplifying full length Casp6 mRNA in WT and truncated Casp6 mRNA in the KO. (B) Number of hyperplasia per colon induced by AOM-DSS treatment 20 weeks post AOM injection. (C) Number of tumors per colon induced by AOM-DSS treatment 20 weeks after AOM injection. (D) Tumor load per mouse in mice after AOM/DSS treatment. (E) Number of tumors per mouse located in proximal, middle or distal part of colons. (B-E) Statistics were performed using one way ANOVA followed by Tukey-Kramer post hoc analysis.