SAMP mice show dysplasia in the absence of AOM treatment after repeated cycles of DSS administration.

<p>Schematic representation of DSS-induced colitis in SAMP and AKR mice (A). Body weight loss (B), expressed as the percentage of initial body weight, * <i>P</i> < 0.05; n ≥ 6 and DAI scores (C) were higher after chronic DSS-colitis induction in SAMP compared to AKR controls. * <i>P</i> < 0.05, ** <i>P</i> < 0.01; n ≥ 6. High-resolution endoscopic images with white light and NBI of distal colons together with endoscopic scores (D) (*** <i>P</i> = 0.0006; n ≥ 6) and representative photomicrographs of colon sections stained with H&E as well as total inflammatory scores (E) (* <i>P</i> = 0.0016; n ≥ 6) are shown for AKR and SAMP mice.