Regional plots showing meta-analyses results for rDR-L.

<p>(A) Results with the top associated SNP in the <i>APOE</i> region labeled. Two conditional meta-analyses were performed for rDR-L, (B) estimating the association with the <i>APOE</i> SNP shown (rs769449), conditioning on the top <i>TOMM40</i> SNP (rs2075650); and (C) estimating the association with the <i>TOMM40</i> SNP shown (rs2075650), conditioning on the top <i>APOE</i> SNP (rs769449). The y-axis shows -log₁₀ P-values; x-axis shows position of genes on chromosome 19 with SNPs 400-kb in both directions of the SNP of interest. The diamond represents the top SNP of interest. The circles represent each genotyped SNP in this region; the circle color indicates pairwise linkage disequilibrium (LD) in relation to the top SNP (calculated from hg19/1000 Genomes Nov 2014 EUR). The solid (blue) line indicates the recombination rate.