Regional Manhattan plots around the SNP markers showing genome-wide significance in the GWA studies.

<p><i>P</i>-values, gene organization, and linkage disequilibrium (LD) plots according to the chromosomal position of the three significantly genome-wide associated regions for NAFLD (A-C) and the one region for NASH-HCC (D). Each figure spans 200 kb (A, B, and D) or 300 kb (C) in both the 5’ and 3’ directions from the SNP with the strongest association (shown with a red arrow) in the GWA studies. <i>P</i>-values are plotted for both genotyped and imputed SNPs in the upper panels, and previously reported SNPs with genome-wide significance are indicated by green arrows. The colors of the circles representing <i>p</i>-values correspond to the strength of LD (r2) from the most significant SNP in the GWA studies. The brightness of the red color in the LD plots in the lower panels also corresponds to the strength of LD.