Structural abnormalities in sub-cortical structures of IUGR animals.

<p>Animals with IUGR displayed differences in sub-cortical structures when compared to Sham animals. Internal capsule size was reduced in both mild and moderate IUGR groups (A). The number of Olig2+ cells in the internal capsule remained unchanged (B). The optic chiasm showed similar results as the internal capsule (C), in addition to fewer OLs in the mildly injured group (D). There was no significant difference in the size of the nucleus accumbens between IUGR and sham animals (E). There were, however, fewer Olig2+ OLs in the nucleus accumbens of both mild and moderate IUGR animals when compared to sham animals (F). The septofimbrial and lateral septal nuclei were decreased in size in IUGR animals relative to sham controls (G). The pretectal nucleus was also significantly decreased in size in moderate IUGR animals only when compared to sham animals (H). *p<0.05; **p<0.01; ***p<0.001.