MRI reveals differences between moderate IUGR and sham animals.

<p>At 3 weeks, abnormalities in both axial and radial diffusivities in white and grey matter were evident in moderate IUGR animals. (A) Representative T2-weighted images and fractional anisotropy (FA) maps, highlighting locations of ROIs in the corpus callosum (CC), external capsule (EC), and caudate (CA) at three anatomical levels (g: genu; b: body; and s: splenium). (B) Representative FA, axial diffusivity, and radial diffusivity maps at the level of the genu from sham and moderate IUGR rats. Note the higher radial diffusivities in the CC of the moderate IUGR animal when compared to sham, with similar FA and axial diffusivities. (C) Tabulated DTI metrics across the sham and moderate IUGR cohorts. Locations of significant differences are highlighted by * (p<0.05) and ** (p<0.01). (D) Graphical display of radial diffusivities in each ROI location for the moderate injury cohort (*p<0.05; **p<0.01).