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Full list of author information is available at the end of the articleDespite the impressive scientific progress in vaccination and chemotherapy, infectious diseases remain a serious health issue. Following the massive and inappropriate use of antibiotics, bacteria have developed various mech-anism of resistance; consequently, infectious diseases re-main one of the leading causes of morbidity worldwide [1]. Microbial infections constitute a major public health problem in developing countries [2] where the high cost of the population. Therefore, the discovery of new anti-microbial agents is still relevant nowadays. Among the bacterial resistance mechanisms, efflux of antibiotics plays an important role; In fact it is widely recognized that the expression of efflux pumps encoded by house-keeping genes in bacteria is largely responsible for the phenomenon of intrinsic antibiotic resistance [3]. Also, the shortcomings of the drugs available today and the scarcity of novel antibiotics propel the discovery of new chemotherapeutic agents from medicinal plants [4]. The medicinal properties of many phytochemicals have bee