RESEARCH ARTICLE Synthesis and antibacteria

Full list of author information is available at the end of the articleIntroduction Fluoroquinolones which are synthetic antibacterial agents are useful for the treatment of urinary tract infections, soft tissue infections, respiratory infections, typhoid fever, sexu-ally transmitted diseases, bone-joint infections, community-acquired pneumonia, acute bronchitis, and sinusitis [1]. Fluoroquinolones consist of a bicyclic ring structure in which there is a substitution at position N-1; most of the current agents have a carboxyl group at position 3, a keto group at position 4, a fluorine atom at position 6 and a nitrogen heterocyclic moiety at the C-7 position [2]. Piperazine substitution at C-7 position has resulted in a wide range of clinically useful fluoroquinolone antibac-terial agents namely norfloxacin (1), ciprofloxacin (2), ofloxacin (3) and levofloxacin (4) [3,4]. Fluoroquinolones with 7-piperazinyl moiety have been reported to posses