This work focuses on 3D interaction with virtual objects, more specifically on 3D manipulation: selection, translation, and rotation. The most commonly-used interaction platforms (personal computer, mobile device) were designed for 2D interaction and thus are not well suited to 3D manipulation. There is a more efficient alternative for this task: virtual reality. However, current virtual reality systems are too often bulky, expensive and/or intrusive to the user, and for these reasons remain underused. In this thesis, we propose and study new solutions to make this form of interaction more convenient without reducing its effectiveness. The main objectives we aim for are interface portability, non-intrusiveness, and the use of readily-availa...