In HMI design, several parameters have to be correctly evaluated in order to guarantee a good level of safety and well-being of users (humans) and to avoid health problems like muscular-skeletal diseases. ISO Standards give us a good reference on Ergonomics and Comfort: ISO 11228 regulation deals with several parameters for evaluating Postural Ergonomics in manual loads’ push/pull, in manual loads’ lifting and carrying and in repetitive actions. Those parameters can be synthesized in a “Postural Load Index” that represents the Ergonomics level of examined posture. Nothing has be done, by ISO, in order to give a method/criterion for evaluating comfort performances of products and workplaces. More than 100.000 scientific papers dealing with c...