In Human-Machine Interface (HMI) design, several parameters have to be correctly evaluated in order to guarantee a good level of safety and well-being of users (humans) and to avoid health problems like muscular-skeletal disease. ISO Standards give us a good reference on Ergonomics and Comfort: ISO 11228 regulation; it deals with qualitative/quantitative parameters for evaluating Postural Ergonomics, using a "Postural Load Index", in push/pull, in manual loads' lifting and carrying and in repetitive actions; those parameters can represent the Ergonomics level of examined posture. While bibliographic references suggest different methods to make ergonomic evaluation like RULA, LUBA and REBA, the state of the art about comfort/discomfort evalu...