Adrenal secretion of estrogens, glucocorticosteroids and mineralocorticosteroids in the dog

The secretion rates of cortisol, corticosterone, aldosterone, estradiol and estrone by isolated adrenal glands perfused in situ were compared to each other. The following conclusions are drawn: 1. 1. The canine adrenal gland is capable of secreting estrogens bu the secretion is extremely low even under intense ACTH stimulation. By extrapolation, this suggests that most of the estrogens produced by castrate or postmenopausal women might derive from a peripheral conversion of the adrenal androgens. 2. 2. In nephrectomized dogs the adrenal cortex behaves as a single functional unit with respect to cortisol, corticosterone and aldosterone secretion in response to various degrees of ACTH stimulation. This observation stresses the non-specific dependence of aldosterone on ACTH. © 1973.SCOPUS: ar.j