The secretory rate of aldosterone in man.

From 1927 to 1930 various groups of investigators demonstrated that adrenal cortical extracts were capable of prolonging the life of adrenalectomized cats (1-4) and dogs (5). Subsequently, Wintersteiner, Vars and Pfiffner (6,7) showed that after the removal of various crystalline substances from adrenal cortical extracts, a non-crystallizable amorphous residue remained which was more active than the separated crystalline components in maintaining the life of an adrenalectomized dog. Kendall, Mason and associates (8) also found that the most physiologically active traction remained in solution and that it was at least ten times more active than compound B. similar findings were reported by Kuizenga and Cartland (9)