Identification of <i>c</i>₁ and <i>c</i>₂, and sensitivity analysis of the differentiation rate of progenitor cells.

(A) The probabilities in 0.1 increments for age-dependent distributions of CD201+CD150+HSC population calculated from Eq (10) and the estimated boundaries of cell division types (i.e., the two thresholds: dashed lines) are shown. (B-E) The results of model fitting to the cell count data in the same procedure of Fig 4B and 4C with differentiation rates of progenitor cells, d, fixed as 0.05 (B, D) and 0.2 (C, E), respectively. Dots and error bars in (B) and (C) are the averages and standard deviations of the experimental data. The lines and filled area in (B) and (C) are the mean and 95% credible intervals predicted by the mathematical model. (D, E) The corresponding age-dependent distributions of S-S, S-P, and P-P divisions in mice were calculated. (TIF)