Age-dependent distribution of three division modes of HSCs.

(A) Overview of the mathematical model describing the dynamics of HSC differentiation. HSCs proliferate by self-renewal and differentiate into the progenitor population. The types of HSC division are defined by the proportion of CD201+CD150+KSL cells. Progenitor cells decrease due to the differentiation into more differentiated cells and mortality. (B) The age-related number of CD34-CD150+KSL cells (HSCs, left) and KSL cells (HSCs and progenitor cells, right) in femur predicted by the mathematical model (Eqs (5) and (6)) with best-fit parameters and the experimental data are shown. The lines and filled area are corresponding to the mean and 95% credible interval, respectively, and the dots and error bars are the average and standard deviations. (C) The expected age-dependent distributions of S-S, S-P, and P-P divisions in mice were calculated.