<p>(<b>A</b>) In the young mouse cohort (age<5.5 months), negative controls are shown in red bars (n=5), and +TET are shown in grey bars (n=16). Organs with statistically significant increased numbers of GFP+ cells groups are indicated by ** above the error bars. (<b>B</b>) In the older mouse cohort (age>8 months), negative controls are shown in red bars (n=11) and +TET are shown in black bars (n=31). (<b>C</b>) Comparison of +TET young mice (grey bars) versus +TET old mice (black bars) from A and B. Organs with statistically significant different numbers of GFP+ cells by age are indicated by ** above the error bars. For all panels, H=heart, P=pancreas, Li=liver, K=kidney, S=spleen, Lu=lung, T=thymus.</p
<p>Percent change in whole brain and brain region volumes between 3 and 9 months of age for WT (blue...
<p><b>(A,B)</b> Plots show proportion of GFP<sup>-</sup> <b>(A)</b> and numbers of GFP<sup>+</sup> a...
<p>Results are mean ± SD. Numbers in brackets denote the number of 2 to 3 mo old female mice examine...
<p>The number of GFP+ cells in each organ of analyzed mice was determined. Establishment of gates is...
<p>All GC species in WT mice showed age-dependent decrease with age (from <1 d, 6–9 wks to 52 wks) i...
<p>Bar graphs depicting the total number of Fo, MZ and T1 B cells in the spleen of 2 month old (<b>A...
(A) Overview of the in vivo experiments. The numbers of CD34-CD150+HSCs and KSL cells in bone marrow...
<p><b>A–D.</b> Representative cross-sections of MOB cut horizontally from four different age groups:...
<p>(<b>A</b>) Representative FACS profiles showing the expression of <i>Meis1</i> by CD45<sup>−</sup...
<p>Left panel shows the main 55-kDa band among multiple bands of representative blots for 3-NT. Righ...
The expected distributions of S-S (red), S-P (green), and P-P (blue) divisions in mice at the specif...
<p>(A) number of BrdU positive islet cells per 10<sup>5</sup> cells (N<sub>(BrdU)</sub>), (B) total ...
<p>A) Number of Ki67 positive cells/field at different ages after birth. Each data point is the mean...
<p><b>(A)</b> Thymus involution in <i>Foxn1</i><sup><i>G/+</i></sup> mice occurs with normal kinetic...
<p>Each panel presents GC species levels in mice having the indicated <i>Gba1</i> mutation: D409H (9...
<p>Percent change in whole brain and brain region volumes between 3 and 9 months of age for WT (blue...
<p><b>(A,B)</b> Plots show proportion of GFP<sup>-</sup> <b>(A)</b> and numbers of GFP<sup>+</sup> a...
<p>Results are mean ± SD. Numbers in brackets denote the number of 2 to 3 mo old female mice examine...
<p>The number of GFP+ cells in each organ of analyzed mice was determined. Establishment of gates is...
<p>All GC species in WT mice showed age-dependent decrease with age (from <1 d, 6–9 wks to 52 wks) i...
<p>Bar graphs depicting the total number of Fo, MZ and T1 B cells in the spleen of 2 month old (<b>A...
(A) Overview of the in vivo experiments. The numbers of CD34-CD150+HSCs and KSL cells in bone marrow...
<p><b>A–D.</b> Representative cross-sections of MOB cut horizontally from four different age groups:...
<p>(<b>A</b>) Representative FACS profiles showing the expression of <i>Meis1</i> by CD45<sup>−</sup...
<p>Left panel shows the main 55-kDa band among multiple bands of representative blots for 3-NT. Righ...
The expected distributions of S-S (red), S-P (green), and P-P (blue) divisions in mice at the specif...
<p>(A) number of BrdU positive islet cells per 10<sup>5</sup> cells (N<sub>(BrdU)</sub>), (B) total ...
<p>A) Number of Ki67 positive cells/field at different ages after birth. Each data point is the mean...
<p><b>(A)</b> Thymus involution in <i>Foxn1</i><sup><i>G/+</i></sup> mice occurs with normal kinetic...
<p>Each panel presents GC species levels in mice having the indicated <i>Gba1</i> mutation: D409H (9...
<p>Percent change in whole brain and brain region volumes between 3 and 9 months of age for WT (blue...
<p><b>(A,B)</b> Plots show proportion of GFP<sup>-</sup> <b>(A)</b> and numbers of GFP<sup>+</sup> a...
<p>Results are mean ± SD. Numbers in brackets denote the number of 2 to 3 mo old female mice examine...