Uvod: Asparaginaza je osnovna komponenta kemoterapijskih protokola za liječenje pedijatrijske akutne limfoblastične leukemije (ALL) i ključan citostatik za postizanje 5-godišnje stope preživljenja oko 90% u razvijenim zemljama. Primjena asparaginaze udružena je sa značajnom toksičnosti. Cilj rada je ispitati učestalost, vrstu i intenzitet toksičnih učinaka asparaginaze te njihov utjecaj na konačni ishod liječenja. Materijali i metode: U istraživanje je uključeno 33 djece (21 dječak i 12 djevojčica) s novodijagnosticiranom ALL, prosječne dobi 5,95±3,45 godina, koja su liječena na Zavodu za hematologiju, onkologiju i kliničku genetiku Klinike za pedijatriju Kliničkog bolničkog centra Rijeka od 1. siječnja 2013. do 31. prosinca 2022. godine. U...
Asparaginase and methotrexate (MTX), both essential for pediatric acute lymphoblastic leukemia thera...
Background Survival for childhood acute lymphoblastic leukaemia surpasses 90% with contemporary ther...
The history of asparaginase clinical use is inextricably linked to the improvement of treatment prog...
Uvod: Asparaginaza je osnovna komponenta kemoterapijskih protokola za liječenje pedijatrijske akutne...
Akutna limfoblastična leukemija (ALL) najučestalija je zloćudna novotvorina dječje dobi s ukupnim pr...
Asparaginase is an integral component of multiagent chemotherapy regimens for the treatment of child...
__Abstract__ Intensified and effective asparaginase therapy is very important in modern treatment...
Michael E RyttingDepartment of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Cente...
Acute lymphoblastic leukemia (ALL) is a form of blood cancer that affects white blood cells and is a...
In acute lymphoblastic leukemia (ALL) patients treated with L-asparaginase, discontinuation of the d...
L-asparaginase (L-Aspa) is utilized as a part of the therapy in children with acute lymphoblastic le...
Asparaginase is one of the most important chemotherapeutic agents against pediatric acute lymphoblas...
Truncation of asparaginase treatment due to asparaginase-related toxicities or silent inactivation (...
l-Asparaginase (EC 3.5.1.1) was first used as a component of combination drug therapies to treat acu...
To access publisher's full text version of this article click on the hyperlink belowTruncation of as...
Asparaginase and methotrexate (MTX), both essential for pediatric acute lymphoblastic leukemia thera...
Background Survival for childhood acute lymphoblastic leukaemia surpasses 90% with contemporary ther...
The history of asparaginase clinical use is inextricably linked to the improvement of treatment prog...
Uvod: Asparaginaza je osnovna komponenta kemoterapijskih protokola za liječenje pedijatrijske akutne...
Akutna limfoblastična leukemija (ALL) najučestalija je zloćudna novotvorina dječje dobi s ukupnim pr...
Asparaginase is an integral component of multiagent chemotherapy regimens for the treatment of child...
__Abstract__ Intensified and effective asparaginase therapy is very important in modern treatment...
Michael E RyttingDepartment of Pediatrics and Leukemia, University of Texas MD Anderson Cancer Cente...
Acute lymphoblastic leukemia (ALL) is a form of blood cancer that affects white blood cells and is a...
In acute lymphoblastic leukemia (ALL) patients treated with L-asparaginase, discontinuation of the d...
L-asparaginase (L-Aspa) is utilized as a part of the therapy in children with acute lymphoblastic le...
Asparaginase is one of the most important chemotherapeutic agents against pediatric acute lymphoblas...
Truncation of asparaginase treatment due to asparaginase-related toxicities or silent inactivation (...
l-Asparaginase (EC 3.5.1.1) was first used as a component of combination drug therapies to treat acu...
To access publisher's full text version of this article click on the hyperlink belowTruncation of as...
Asparaginase and methotrexate (MTX), both essential for pediatric acute lymphoblastic leukemia thera...
Background Survival for childhood acute lymphoblastic leukaemia surpasses 90% with contemporary ther...
The history of asparaginase clinical use is inextricably linked to the improvement of treatment prog...