A new approach to sepsis care

Sepsis is among the most lethal medical conditions, posing a universal threat to most healthcare systems throughout the globe. Although sepsis occurs because the immune system is mounting a response to infection, it paradoxically harms the body, leading to a rapid deterioration of most organ functions. The successful uptake and subsequent implementation of sepsis care bundles across healthcare institutions has led to a decrease in sepsis-related morbidity and mortality. However, despite these ongoing advances, current treatment protocols often fail to address the underlying pathology of the inflammatory response that drives sepsis. Pharmaconutrients, or pharmacologically active nutrients, may reduce the hyperinflammatory response that underpins sepsis, and serve as potential adjuvants to current care protocols. While considering the global burden of sepsis, this review will highlight the importance of revising the current approach to sepsis care by examining the role of pharmaconutrition as a novel therapy