Sepsis: A Re-Look At Updates In 2019

Sepsis remains the one of the leading causes of mortality and morbidity worldwide. Though there have been continuous advancements in its understanding and management, it remains a deadly entity. The latest definition of sepsis given by the Sepsis-3 guidelines in the year 2016, stated sepsis to be a life-threatening organ dysfunction due to dysregulated host response to infection. The new recommendations include the use of balanced fluids for resuscitation, nor-ephinephrine as the first vasopressor of choice, steroids use in septic shock refractory to fluid resuscitation and vasopressors, using Sequential Organ Failure Assessment (SOFA) score for rapid identification of patients with sepsis, quick SOFA (qSOFA) score to identify patients at risk of sepsis outside intensive care unit, and new the therapeutic options of angiotensin II, vitamin C, and thiamine that need further validation in managing sepsi