A Review Article On Solubility Enhancement Techniques

This review's objective is to investigate several factors that could enhance the solubility and bioavailability of medications that aren't very water soluble. Due to the ease of consumption for many medications, the oral route of administration is the most popular and widely accepted method of delivery. When taken orally, medications with slow dissolution rates exhibit partial absorption that results in limited bioavailability. The solubility of drugs that are poorly soluble in water has been improved using a variety of techniques, including particle size reduction, micronization, cosolvency, hydrotropy, pH adjustment, sonocrystallization, supercritical antisolvent technique, solid dispersion, inclusion complexation, micro emulsion, and liquid solid methods. The writers of this review covered a number of methods for improving drug absorption and bioavailability as well as a number of solubility improvement patent