SOLUBILITY ENHANCEMENT OF POORLY WATER SOLUBLE DRUGS: A REVIEW

ABSTRACT: Many water insoluble drugs present in class 2 and it is characterized by low solubility and high permeability. Solubility of drug can be enhancing by increasing of dissolution rate. Many solubilization techniques are available for increasing of solubility as well as permeability like micronization, coacervation, complexation, solid dispersion, and cosolvent. Poorly soluble and dissolution profile creates problem in pharmaceutical industry for development of dosage form. Solid dispersions are the most attractive method for improving of bioavailability of poorly water soluble drugs. Reduction of particle size leads to increase in wettability and porosity of drugs. Porosity and wettability improves the solubility and dissolution rate. INTRODUCTION: Biopharmaceutical Classifi-cation System (BCS) based on its solubility and permeability. Bioavailability of drug affected by three major factor like solubility, permeability an