A Brief Review on Solubility Enhancement Techniques with Drug and Polymer

ABSTRACT: The process of a solid dissolving in a liquid phase to create a homogenous mixture is known as solubility. A crucial factor in getting the right quantity of drug into the bloodstream to show a pharmacological effect is solubility. The main issue in developing formulations for new chemical entities as well as for the creation of generics is low water solubility. More than 40% of novel chemical entities (NCEs) created in the pharmaceutical sector are essentially water insoluble. For formulation scientists, solubility is a significant challenge. Any medicine that is to be absorbed at the absorption site must be there in solution form. The solubility of pharmaceuticals that are poorly soluble can be improved using a variety of approaches, such as complexation, salt formation, particle size reduction, crystal engineering, salt formation, solid dispersion, and the like. The choice of a solubility-improving technology is influenced by pharmacological properties, absorption sites, and the requirements for the dosage form. This review article's goal is to improve bioavailability and promote effective absorption