Fig. 8. Proposed biotransformation process of artemisinic acid (AA) by Penicillium oxalicum B4.Published as part of Tian, Hao, Li, Xin Ping, Zhao, Jianping, Gao, Hong Wei, Xu, Qiong Ming & Wang, Jian Wen, 2021, Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L., pp. 1-10 in Phytochemistry (112682) 185 on page 8, DOI: 10.1016/j.phytochem.2021.112682, http://zenodo.org/record/825969
The antimalarial drug artemisinin is a natural product produced by the plant Artemisia annua. Extrac...
Artemisia annua has a long history of use in traditional Chinese medicine. We determined that A. afr...
An important group of antimalarial drugs consists of the endoperoxide sesquiterpene lactone artemisi...
Tian, Hao, Li, Xin Ping, Zhao, Jianping, Gao, Hong Wei, Xu, Qiong Ming, Wang, Jian Wen (2021): Biotr...
Fig. 1. Structures of artemisinic acid (AA) and its biotransformation metabolites 1–8.Published as p...
Fig. 5. Time course for the biotransformation of artemisinic acid (AA) by Penicillium oxalicum B4. A...
Fig. 4. Time course of mycelial biomass (A) and the biotransformation of artemisinic acid (AA) by Pe...
Fig. 6. Cytotoxic activity induced by artemisinic acid (AA) and its derivatives in HL60 (A), LS174T ...
Fig. 3. Key NOSEY correlations for metabolites 1–4.Published as part of Tian, Hao, Li, Xin Ping, Zha...
Fig. 2. Key HMBC and 1H-1H COSY correlations for metabolites 1–5.Published as part of Tian, Hao, Li,...
Fig. 7. Inhibitory effects of metabolite 4 (A) and 7 (B) on cell viability and LPSinduced nitrite pr...
Metabolic engineering is an integrated bioengineering approach, which has made considerable progress...
Oleanolic acid (1) is a bioactive compound widely distributed in nature. Microbial transformation is...
Artemisinin, a sesquiterpene lactone, is the active antimalarial constituent of Artemisia annua. Sev...
Metabolic engineering is an integrated bioengineering approach, which has made considerable progress...
The antimalarial drug artemisinin is a natural product produced by the plant Artemisia annua. Extrac...
Artemisia annua has a long history of use in traditional Chinese medicine. We determined that A. afr...
An important group of antimalarial drugs consists of the endoperoxide sesquiterpene lactone artemisi...
Tian, Hao, Li, Xin Ping, Zhao, Jianping, Gao, Hong Wei, Xu, Qiong Ming, Wang, Jian Wen (2021): Biotr...
Fig. 1. Structures of artemisinic acid (AA) and its biotransformation metabolites 1–8.Published as p...
Fig. 5. Time course for the biotransformation of artemisinic acid (AA) by Penicillium oxalicum B4. A...
Fig. 4. Time course of mycelial biomass (A) and the biotransformation of artemisinic acid (AA) by Pe...
Fig. 6. Cytotoxic activity induced by artemisinic acid (AA) and its derivatives in HL60 (A), LS174T ...
Fig. 3. Key NOSEY correlations for metabolites 1–4.Published as part of Tian, Hao, Li, Xin Ping, Zha...
Fig. 2. Key HMBC and 1H-1H COSY correlations for metabolites 1–5.Published as part of Tian, Hao, Li,...
Fig. 7. Inhibitory effects of metabolite 4 (A) and 7 (B) on cell viability and LPSinduced nitrite pr...
Metabolic engineering is an integrated bioengineering approach, which has made considerable progress...
Oleanolic acid (1) is a bioactive compound widely distributed in nature. Microbial transformation is...
Artemisinin, a sesquiterpene lactone, is the active antimalarial constituent of Artemisia annua. Sev...
Metabolic engineering is an integrated bioengineering approach, which has made considerable progress...
The antimalarial drug artemisinin is a natural product produced by the plant Artemisia annua. Extrac...
Artemisia annua has a long history of use in traditional Chinese medicine. We determined that A. afr...
An important group of antimalarial drugs consists of the endoperoxide sesquiterpene lactone artemisi...