Fig. 7 in Biotransformation of artemisinic acid to bioactive derivatives by endophytic Penicillium oxalicum B4 from Artemisia annua L.

Fig. 7. Inhibitory effects of metabolite 4 (A) and 7 (B) on cell viability and LPSinduced nitrite production in RAW 264.7 cells. Normal cells were incubated for 24 h with metabolite 4 and 7 at indicated concentrations. Cells were pretreated with the indicated concentrations of metabolite 4 and 7 for 1 h followed by treatment with LPS (1.0 μg/mL). After 24 h of incubation, the amount of nitrite in the culture supernatants and cell viability were measured. Data presented are the means ± SD of results from three independent experiments (###p <0.001 versus untreated group; *p <0.05, **p <0.01 versus LPS treated group. The small letters indicate the significant difference (p