Forest plots investigating impact of time since model induction on rat thigmotaxis.

Forty-one cohort-level comparisons assessed the impact of nerve injury models at (A) different time points (number of hours from model induction to the first OFT assessment) to sham control on rat thigmotaxis. (B) Time block analysis. For each comparison, an effect size was calculated using the Hedge’s g SMD method. Effect sizes were pooled using the random effects model. The size of the square represents the weight, which reflects the contribution of each comparison with the pooled effect estimate. CI, confidence interval; k, number of cohort-level comparisons.