Forest plot of impact of modelling on mouse thigmotaxis.

A summary forest plot of the 116 cohort-level comparisons which assessed the impact of modelling compared to sham control on mouse thigmotaxis. For each comparison, an effect size was calculated using the Hedges’ g SMD method. Effect sizes were pooled using the random effects model. The restricted maximum-likelihood method was used to estimate heterogeneity. The overall effect size is -1.23 [95%CI -1.80 to -0.67]; Q = 4316.72, df = 115, p I2 = 97%. The size of the square represents the weight, which reflects the contribution of each comparison with the pooled effect estimate. TIC, time spent in the centre; TIP, time spent in the periphery. CI, confidence interval; N, number of animals.