Simulated human hepatocytes infection kinetics post simulated inoculation.

(A) Uninfected cells (T, black line), Infected non-productive cells (IE, yellow line), and productively infected cells (IP, red line) kinetics. The bold lines of each simulation curve represent the average of 1,000 independent runs with different random seeds and the shaded areas denote 95% confidence interval of those 1,000 runs. (B) Cell states observed from a representative run in the 2D lattice at 1, 2, 3, and 6 weeks post simulated inoculation. Uninfected cells (T, black cells), Infected non-productive cells (IE, yellow cells), and productively infected cells (IP, red cells). The ABM results shown represent the best fit of mouse M1 (Fig 3A and Table 1). The spatial structure on the 2D lattice was not considered in the ABM to affect viral infection spread.