Effects of model parameter values on predicted infection dynamics in mammalian cells.

Predicted RVFV infection dynamics in mammalian cells for three different scenarios: selective genome packaging (finely dotted blue lines), non-selective genome packaging without co-infection by incomplete particles (coarsely dotted green lines), and non-selective genome packaging with co-infection and productive complementation by incomplete particles (solid magenta lines). The darker lines (each color corresponding to a different scenario) represent the mean values based on 1,000 simulations. The faint dotted lines (each color corresponding to a different scenario) represent trajectories for 20 individual simulations. In all panels, time is on the x axis and the number of infected cells is on the y axis. Note that the axes are scaled differently over panels. Values for the total number of cells (κ) and virus particle production (φ) were varied over panels, as indicated by the values at the top and right of the figure, respectively. Infection dynamics are clearly affected by parameter values, but under many conditions, the virus employing non-selective packaging but that allows co-infection has an advantage over the virus employing non-selective packaging without co-infection. The code required to reproduce the plots of this figure is provided as S3 File. (PNG)