Effect of different forms of viral infection on the therapeutic outcome.

Simulation outcome in relation to the rates of viral spread via contact (bi) and death rate of infected cells (di) in the 3D model for three different forms of viral infection. As indicated in the illustration on the left, virus infection in the tumour is initiated either in the centre (top row), or from the periphery (middle row), or in a random manner (bottom row). For each infection scenario 50,000 simulations were run, which were classified according to (A) their therapeutic outcomes; and (B) the number of the different types of cells at the end of the simulations. All parameters were at their default values. The colour code is based on the logarithm of cell numbers. (TIF)