Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P=4.5×10-8-1.2×10-43). Using a novel method to combine data across ethnicities (N=4,232 African Americans, N=1,776 Asians, and N=29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 genes at candidat...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly herita...