Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
- Dastani, Zari
- Hivert, Marie-France
- Timpson, Nicholas
- Perry, John R. B.
- Yuan, Xin
- Scott, Robert A.
- Henneman, Peter
- Heid, Iris M.
- Kizer, Jorge R.
- Lyytikainen, Leo-Pekka
- Fuchsberger, Christian
- Tanaka, Toshiko
- Morris, Andrew P.
- Small, Kerrin
- Isaacs, Aaron
- Beekman, Marian
- Coassin, Stefan
- Lohman, Kurt
- Qi, Lu
- Kanoni, Stavroula
- Pankow, James S.
- Uh, Hae-Won
- Wu, Ying
- Bidulescu, Aurelian
- Rasmussen-Torvik, Laura J.
- Greenwood, Celia M. T.
- Ladouceur, Martin
- Grimsby, Jonna
- Manning, Alisa K.
- Liu, Ching-Ti
- Kooner, Jaspal
- Mooser, Vincent E.
- Vollenweider, Peter
- Kapur, Karen A.
- Chambers, John
- Wareham, Nicholas J.
- Langenberg, Claudia
- Frants, Rune
- Willems-vanDijk, Ko
- Oostra, Ben A.
- Willems, Sara M.
- Lamina, Claudia
- Winkler, Thomas W.
- Psaty, Bruce M.
- Tracy, Russell P.
- Brody, Jennifer
- Chen, Ida
- Viikari, Jorma
- Kahonen, Mika
- Pramstaller, Peter P.
- Evans, David M.
- St Pourcain, Beate
- Sattar, Naveed
- Wood, Andrew R.
- Bandinelli, Stefania
- Carlson, Olga D.
- Egan, Josephine M.
- Bohringer, Stefan
- van Heemst, Diana
- Kedenko, Lyudmyla
- Kristiansson, Kati
- Nuotio, Marja-Liisa
- Loo, Britt-Marie
- Harris, Tamara
- Garcia, Melissa
- Kanaya, Alka
- Haun, Margot
- Klopp, Norman
- Wichmann, Heinz-Erich
- Deloukas, Panos
- Katsareli, Efi
- Couper, David J.
- Duncan, Bruce B.
- Kloppenburg, Margreet
- Adair, Linda S.
- Borja, Judith B.
- Wilson, James G.
- Musani, Solomon
- Guo, Xiuqing
- Johnson, Toby
- Semple, Robert
- Teslovich, Tanya M.
- Allison, Matthew A.
- Redline, Susan
- Buxbaum, Sarah G.
- Mohlke, Karen L.
- Meulenbelt, Ingrid
- Ballantyne, Christie M.
- Dedoussis, George V.
- Hu, Frank B.
- Liu, Yongmei
- Paulweber, Bernhard
- Spector, Timothy D.
- Slagboom, P. Eline
- Ferrucci, Luigi
- Jula, Antti
- Perola, Markus
- Raitakari, Olli
- Florez, Jose C.
- Salomaa, Veikko
- Eriksson, Johan G.
- Frayling, Timothy M.
- Hicks, Andrew A.
- Lehtimaki, Terho
- Smith, George Davey
- Siscovick, David S.
- Kronenberg, Florian
- van Duijn, Cornelia
- Loos, Ruth J. F.
- Waterworth, Dawn M.
- Meigs, James B.
- Dupuis, Josee
- Richards, J. Brent
DOIAbstract
Circulating levels of adiponectin, a hormone produced predominantly by adipocytes, are highly heritable and are inversely associated with type 2 diabetes mellitus (T2D) and other metabolic traits. We conducted a meta-analysis of genome-wide association studies in 39,883 individuals of European ancestry to identify genes associated with metabolic disease. We identified 8 novel loci associated with adiponectin levels and confirmed 2 previously reported loci (P=4.5 x 10(-8)-1.2 x 10(-43)). Using a novel method to combine data across ethnicities (N = 4,232 African Americans, N = 1,776 Asians, and N = 29,347 Europeans), we identified two additional novel loci. Expression analyses of 436 human adipocyte samples revealed that mRNA levels of 18 gen...
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