(A and B) Immunofluorescence images of γH2AX and pTDP-43 (pS409/410) staining OrgCtrl (A) or OrgALS cerebral organoids (B) at 8 weeks p.i. of protein extract from control (control 1) or ALS (patient 2). A higher magnification of white line box is shown in the right inset. DAPI was used for counterstaining of nuclei. Arrow heads indicate γH2AX nuclear foci. Scale bars = 50 μm (10 μm for inset). (C) Quantification analysis of γH2AX staining immunofluorescence images of OrgCtrl and OrgALS cerebral organoids at 8 weeks p.i. of protein extract from individual controls (control 1–3) or ALS cases (patient 1–5) represented in (A) and (B). Bar plots show mean ± SD with individual points representing a different protein extract. Percentages of cells ...
Summary: Loss of the nuclear RNA binding protein TAR DNA binding protein-43 (TDP-43) into cytoplasmi...
The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic...
Transactive response DNA-binding protein of 43 kDa (TDP-43) is the major protein found within pathol...
(A and B) Immunofluorescence images of pTDP-43 (pS409/410) and TUJ1 staining OrgCtrl (A) or OrgALS c...
(A and B) Double-labelled immunofluorescence images of pTDP-43 (pS409/410) and TUJ1 staining OrgCtrl...
(A and B) TUNEL stain images of OrgCtrl (A) or OrgALS cerebral organoids (B) at 8 weeks p.i. of prot...
(A and B) Immunofluorescence images of GFAP and TUJ1 staining OrgCtrl (A) or OrgALS cerebral organoi...
Immunofluorescence images of OrgALS cerebral organoid double-labelled with pTDP-43 and GFAP at 8 wee...
International audienceTransactivation response DNA binding protein 43 kDa (TDP-43) is known to be a ...
Transactive response DNA-binding protein 43 kDa (TDP-43) is a highly conserved protein that regulate...
(A) Dot blot analysis of sarkosyl-insoluble protein extracts from non-ALS control (control 1) and C9...
Transactive response DNA binding protein of 43 kDa (TDP-43) is considered to play an essential role ...
International audienceAccumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main patholo...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons (MN) in the brai...
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease with no cure. TAR-DNA...
Summary: Loss of the nuclear RNA binding protein TAR DNA binding protein-43 (TDP-43) into cytoplasmi...
The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic...
Transactive response DNA-binding protein of 43 kDa (TDP-43) is the major protein found within pathol...
(A and B) Immunofluorescence images of pTDP-43 (pS409/410) and TUJ1 staining OrgCtrl (A) or OrgALS c...
(A and B) Double-labelled immunofluorescence images of pTDP-43 (pS409/410) and TUJ1 staining OrgCtrl...
(A and B) TUNEL stain images of OrgCtrl (A) or OrgALS cerebral organoids (B) at 8 weeks p.i. of prot...
(A and B) Immunofluorescence images of GFAP and TUJ1 staining OrgCtrl (A) or OrgALS cerebral organoi...
Immunofluorescence images of OrgALS cerebral organoid double-labelled with pTDP-43 and GFAP at 8 wee...
International audienceTransactivation response DNA binding protein 43 kDa (TDP-43) is known to be a ...
Transactive response DNA-binding protein 43 kDa (TDP-43) is a highly conserved protein that regulate...
(A) Dot blot analysis of sarkosyl-insoluble protein extracts from non-ALS control (control 1) and C9...
Transactive response DNA binding protein of 43 kDa (TDP-43) is considered to play an essential role ...
International audienceAccumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main patholo...
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease of motor neurons (MN) in the brai...
Amyotrophic Lateral Sclerosis (ALS) is a devastating neurodegenerative disease with no cure. TAR-DNA...
Summary: Loss of the nuclear RNA binding protein TAR DNA binding protein-43 (TDP-43) into cytoplasmi...
The RNA/DNA-binding protein, TDP-43, is the key component of ubiquitinated inclusions characteristic...
Transactive response DNA-binding protein of 43 kDa (TDP-43) is the major protein found within pathol...