Immunofluorescence images of OrgALS cerebral organoid double-labelled with pTDP-43 and GFAP at 8 weeks post injection of protein extracts from ALS (patient 5). The lower panels are higher magnifications of the white-line boxes in the upper panels. Scale bars = 50 μm (upper panel) and 10 μm (lower panel). (TIF)</p
Mounting evidence now suggests that many neurodegenerative diseases behave in a similar manner to pr...
TDP-43 is the major component protein of ubiquitin-positive inclusions in brains of patients with fr...
Transactive response DNA-binding protein 43 kD (TDP-43) is an aggregation-prone prion-like domain-co...
(A) Dot blot analysis of sarkosyl-insoluble protein extracts from non-ALS control (control 1) and C9...
(A and B) Immunofluorescence images of pTDP-43 (pS409/410) and TUJ1 staining OrgCtrl (A) or OrgALS c...
(A and B) Double-labelled immunofluorescence images of pTDP-43 (pS409/410) and TUJ1 staining OrgCtrl...
(A and B) Immunofluorescence images of GFAP and TUJ1 staining OrgCtrl (A) or OrgALS cerebral organoi...
(A and B) Immunofluorescence images of γH2AX and pTDP-43 (pS409/410) staining OrgCtrl (A) or OrgALS ...
(A and B) TUNEL stain images of OrgCtrl (A) or OrgALS cerebral organoids (B) at 8 weeks p.i. of prot...
Amyotrophic lateral sclerosis (ALS) is identified histologically by the deposition of phosphorylated...
International audienceAccumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main patholo...
Figure S1. ALS muscle samples from three patients (top, middle, and bottom rows) with pTDP-43-immuno...
AbstractAmyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND), a...
Abstract Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and ...
(A and B) Immunohistochemistry of anterior horn spinal cords stained by TDP-43 antibody. The blue ar...
Mounting evidence now suggests that many neurodegenerative diseases behave in a similar manner to pr...
TDP-43 is the major component protein of ubiquitin-positive inclusions in brains of patients with fr...
Transactive response DNA-binding protein 43 kD (TDP-43) is an aggregation-prone prion-like domain-co...
(A) Dot blot analysis of sarkosyl-insoluble protein extracts from non-ALS control (control 1) and C9...
(A and B) Immunofluorescence images of pTDP-43 (pS409/410) and TUJ1 staining OrgCtrl (A) or OrgALS c...
(A and B) Double-labelled immunofluorescence images of pTDP-43 (pS409/410) and TUJ1 staining OrgCtrl...
(A and B) Immunofluorescence images of GFAP and TUJ1 staining OrgCtrl (A) or OrgALS cerebral organoi...
(A and B) Immunofluorescence images of γH2AX and pTDP-43 (pS409/410) staining OrgCtrl (A) or OrgALS ...
(A and B) TUNEL stain images of OrgCtrl (A) or OrgALS cerebral organoids (B) at 8 weeks p.i. of prot...
Amyotrophic lateral sclerosis (ALS) is identified histologically by the deposition of phosphorylated...
International audienceAccumulation of abnormally phosphorylated TDP-43 (pTDP-43) is the main patholo...
Figure S1. ALS muscle samples from three patients (top, middle, and bottom rows) with pTDP-43-immuno...
AbstractAmyotrophic lateral sclerosis (ALS) is the most common form of motor neuron disease (MND), a...
Abstract Neurodegenerative diseases such as Parkinson's disease (PD), Alzheimer's disease (AD), and ...
(A and B) Immunohistochemistry of anterior horn spinal cords stained by TDP-43 antibody. The blue ar...
Mounting evidence now suggests that many neurodegenerative diseases behave in a similar manner to pr...
TDP-43 is the major component protein of ubiquitin-positive inclusions in brains of patients with fr...
Transactive response DNA-binding protein 43 kD (TDP-43) is an aggregation-prone prion-like domain-co...