SPECIAL EPIGENETIC ISSUE Epigenetic states that allow chromatin fidelity inheritance can be mediated by several factors. One of them, histone variants and their modifications (including acetylation, methylation, phosphorylation, poly(ADP-ribosyl)ation, and ubiquitylation) create distinct patterns of signals read by other proteins, and are strictly related to chromatin remodelling, which is necessary for the specific expression of a gene, and for DNA repair, recombination, and replication. In the framework of chromatin-controlling factors, the poly(ADP-ribosyl)ation of nuclear proteins, catalysed by poly(ADP-ribose)polymerases (PARPs), has been implicated in the regulation of both physiological and pathological events (gene expression/amplif...
International audienceGenotoxic stress generates single-and double-strand DNA breaks either through ...
The process of transcription, which is a vital step in the cellular response to physiological and en...
Epigenetics is the study of hereditable chromatin modifications, such as DNA methylation, histone mo...
SPECIAL EPIGENETIC ISSUE Epigenetic states that allow chromatin fidelity inheritance can be mediated...
The interaction of DNA with proteins in the context of chromatin has to be tightly regulated to achi...
Epigenetic refers to a range of heritable chromatin modifications including DNA methylation, histone...
<div><p>Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking ste...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
Poly(ADP-ribose) polymerase is a nuclear enzyme that is highly conserved in eucaryotes. Its activity...
In the post-genome era attention is being focused on those epigenetic modifications which modulate c...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
Genotoxic stress generates single- and double-strand DNA breaks either through direct damage by re...
One of the key players in genomic structure and dynamics is chromatin modification enzymes, which re...
Poly(ADP-ribos)ylation (PARylation) is the catalytic function of the Poly(ADP-ribose) polymerases (P...
International audienceGenotoxic stress generates single-and double-strand DNA breaks either through ...
The process of transcription, which is a vital step in the cellular response to physiological and en...
Epigenetics is the study of hereditable chromatin modifications, such as DNA methylation, histone mo...
SPECIAL EPIGENETIC ISSUE Epigenetic states that allow chromatin fidelity inheritance can be mediated...
The interaction of DNA with proteins in the context of chromatin has to be tightly regulated to achi...
Epigenetic refers to a range of heritable chromatin modifications including DNA methylation, histone...
<div><p>Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking ste...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
Poly(ADP-ribose) polymerase is a nuclear enzyme that is highly conserved in eucaryotes. Its activity...
In the post-genome era attention is being focused on those epigenetic modifications which modulate c...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
Genotoxic stress generates single- and double-strand DNA breaks either through direct damage by re...
One of the key players in genomic structure and dynamics is chromatin modification enzymes, which re...
Poly(ADP-ribos)ylation (PARylation) is the catalytic function of the Poly(ADP-ribose) polymerases (P...
International audienceGenotoxic stress generates single-and double-strand DNA breaks either through ...
The process of transcription, which is a vital step in the cellular response to physiological and en...
Epigenetics is the study of hereditable chromatin modifications, such as DNA methylation, histone mo...