Poly(ADP-ribose) polymerase is a nuclear enzyme that is highly conserved in eucaryotes. Its activity is totally dependent on the presence of DNA containing single or double stranded breaks. We have shown that this activation results in a decondensation of chromatin superstructure in vitro, which is caused mainly by hyper(ADP-ribosy)ation of histone H1. In core particles, the modification of histone H2B leads to a partial dissociation of DNA from core histones. The conformational change of native chromatin by poly(ADP-ribosyl)ation is reversible upon degradation of the histone H1-bound poly(ADP-ribose) by poly(ADP-ribose) glycohydrolase. We propose that cuts produced in vivo on DNA during DNA repair activate poly(ADP-ribose) polymerase, whic...
Poly (ADP-ribose) polymerase, a nuclear protein-modifying enzyme, binds to the internucleosomal link...
Journal ArticleDNA in eukaryotic chromosomes is organized differently from prokaryotic DNA. It seem...
Epigenetic refers to a range of heritable chromatin modifications including DNA methylation, histone...
It has been demonstrated recently by Poirier et al. (Poirier, G. G., de Murcia, G., Jongstra-Bilen, ...
The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin was analyzed by gel electro...
<div><p>Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking ste...
SPECIAL EPIGENETIC ISSUE Epigenetic states that allow chromatin fidelity inheritance can be mediated...
The interaction of DNA with proteins in the context of chromatin has to be tightly regulated to achi...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
When rat pancreatic polynucleosomes were poly(ADP-ribosyl)ated with purified calf thymus poly(ADP-ri...
It is well-known that H1-H1 interactions are very important for the induction of 30 nm chromatin fib...
International audienceGenotoxic stress generates single-and double-strand DNA breaks either through ...
Genotoxic stress generates single- and double-strand DNA breaks either through direct damage by re...
Poly (ADP-ribose) polymerase, a nuclear protein-modifying enzyme, binds to the internucleosomal link...
Journal ArticleDNA in eukaryotic chromosomes is organized differently from prokaryotic DNA. It seem...
Epigenetic refers to a range of heritable chromatin modifications including DNA methylation, histone...
It has been demonstrated recently by Poirier et al. (Poirier, G. G., de Murcia, G., Jongstra-Bilen, ...
The effect of poly(ADP-ribosyl)ation on native and H1-depleted chromatin was analyzed by gel electro...
<div><p>Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking ste...
SPECIAL EPIGENETIC ISSUE Epigenetic states that allow chromatin fidelity inheritance can be mediated...
The interaction of DNA with proteins in the context of chromatin has to be tightly regulated to achi...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which...
When rat pancreatic polynucleosomes were poly(ADP-ribosyl)ated with purified calf thymus poly(ADP-ri...
It is well-known that H1-H1 interactions are very important for the induction of 30 nm chromatin fib...
International audienceGenotoxic stress generates single-and double-strand DNA breaks either through ...
Genotoxic stress generates single- and double-strand DNA breaks either through direct damage by re...
Poly (ADP-ribose) polymerase, a nuclear protein-modifying enzyme, binds to the internucleosomal link...
Journal ArticleDNA in eukaryotic chromosomes is organized differently from prokaryotic DNA. It seem...
Epigenetic refers to a range of heritable chromatin modifications including DNA methylation, histone...