Additional file 2: Figure sup 2. Lack of effects of cuprizone-induceddemyelination on the blood-brainbarrier integrity among apoE-TR mice. (A) Brain samples ofapoE-TR mice from CPZ-treated group (n=16/genotype) were subjected toimmunofluorescence staining for CLDN5(a tight junction-associated protein) and Glut1 (vascular marker). Representative images of CLDN5 (Green) staining and Glut1 (Red)staining in the CC region of apoE-TR mice are shown. Scale bar, 50 µm. Values are mean ± SEM. One-way ANOVA.N.S. not significant
A) The myelin staining (blue) was strongest in the healthy controls (A1). The cuprizone mice that re...
<p>(a) Representative images of JunB<sup>f/f</sup>/c-Jun<sup>f/f</sup> controls and JunB<sup>Δol</su...
BBB permeability of control and Cstb −/− mice. (A) Levels of sodium fluorescein (NaF) in the brain o...
Additional file 1: Figure sup 1. Opposing effects of apoE2 and apoE4 on Iba1 proteinlevels and their...
Additional file 3: Figure sup 3. Similar levels of astrogliosis were observed in apoE-TR mice upon c...
Additional file 5: Figure sup 5. Transcriptional changes of selected immuneresponse-related genes in...
Additional file 4: Figure sup 4. Transcriptional changes of selected astrocyte-enrichedgenes in apoE...
Additional file 6: Figure sup 6. The key molecules that regulate microglialfunctions are up-regulate...
Radial distribution around arteries is greater for non-lipidated than lapidated apoE4. A-H) Represen...
Figure S1. Time course of cuprizone induced pathology in corpus callosum and cortex. (a) Representat...
Regional analysis of perivascular hemosiderin deposits identifies the brain cortex in mice of all AP...
Figure S1. No microgliosis in both Cre-positive and Cre-negative control mice. (A-D) No differences ...
<p>(A–B) Immunostaining of BrdU-Olig2 (A) and GFAP (B) of the midline corpus callosum of the infused...
The earliest stage of defective cerebellar morphology in Lrp5/6 dCKO mice. (a-d) Nissl staining show...
Specific antibodies for mouse apoE and human apoE4 immunostaining. 5XFAD/apoEm/m and 5XFAD/apoE4/4 b...
A) The myelin staining (blue) was strongest in the healthy controls (A1). The cuprizone mice that re...
<p>(a) Representative images of JunB<sup>f/f</sup>/c-Jun<sup>f/f</sup> controls and JunB<sup>Δol</su...
BBB permeability of control and Cstb −/− mice. (A) Levels of sodium fluorescein (NaF) in the brain o...
Additional file 1: Figure sup 1. Opposing effects of apoE2 and apoE4 on Iba1 proteinlevels and their...
Additional file 3: Figure sup 3. Similar levels of astrogliosis were observed in apoE-TR mice upon c...
Additional file 5: Figure sup 5. Transcriptional changes of selected immuneresponse-related genes in...
Additional file 4: Figure sup 4. Transcriptional changes of selected astrocyte-enrichedgenes in apoE...
Additional file 6: Figure sup 6. The key molecules that regulate microglialfunctions are up-regulate...
Radial distribution around arteries is greater for non-lipidated than lapidated apoE4. A-H) Represen...
Figure S1. Time course of cuprizone induced pathology in corpus callosum and cortex. (a) Representat...
Regional analysis of perivascular hemosiderin deposits identifies the brain cortex in mice of all AP...
Figure S1. No microgliosis in both Cre-positive and Cre-negative control mice. (A-D) No differences ...
<p>(A–B) Immunostaining of BrdU-Olig2 (A) and GFAP (B) of the midline corpus callosum of the infused...
The earliest stage of defective cerebellar morphology in Lrp5/6 dCKO mice. (a-d) Nissl staining show...
Specific antibodies for mouse apoE and human apoE4 immunostaining. 5XFAD/apoEm/m and 5XFAD/apoE4/4 b...
A) The myelin staining (blue) was strongest in the healthy controls (A1). The cuprizone mice that re...
<p>(a) Representative images of JunB<sup>f/f</sup>/c-Jun<sup>f/f</sup> controls and JunB<sup>Δol</su...
BBB permeability of control and Cstb −/− mice. (A) Levels of sodium fluorescein (NaF) in the brain o...