Additional file 2: Figure S2. of APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice

Regional analysis of perivascular hemosiderin deposits identifies the brain cortex in mice of all APOE genotypes and the thalamus in APP/ε2 mice as brain structures susceptible to microbleeds associated with anti-Aβ immunization. Shown are means (± SEM) for counts of all brain perivascular hemosiderin deposits in the brain cortex, the hippocampus, the basal ganglia, the corpus callosum, the thalamus, the septum and the midbrain in APP/ε2 (a), APP/ε3 (b), and APP/ε4 mice (c) (n = 5-11/group). Perivascular hemosiderin deposits were counted on every tenth brain coronal cross-section along the entire rostro-caudal axis of the brain. a through (c) p < 0.0001 (one-way analysis of variance); *p < 0.05, ***p < 0.001, and ****p < 0.0001, TY11-15 control vs. 10D5 mAb treatment for matching brain structures and APOE genotypes (Sidak’s post hoc test). For brain structures where the differences between TY11-15 control and 10D5 mAb treatment groups were not statistically significant p values are not shown. Differences between Age control and TY11-15 groups were non-significant for all structures (Sidak’s post hoc test); p values not shown on the graph. (PDF 419 kb