This paper concerns the numerical characterization of the fatigue strength of a flat stiffened panel, designed as a fibre metal laminates (FML) and made of Aluminium alloy and Fibre Glass FRP. The panel is full scale and was tested under fatigue biaxial loads, applied by means of a multi-axial fatigue machine: an initial through the thickness notch is created in the panel and the aforementioned biaxial fatigue load is applied, causing a crack initiation and propagation. The fatigue test is simulated by the Dual Boundary Element Method (DBEM) in a two-dimensional approach, followed by a 3D BEM sub-modelling analysis, needed to justify the assumptions on delamination area and fibre rupture made in the 2d crack propagation. Due to the lack of ...