A Cell Culture (Vero)–Derived H5N1 Whole-Virus Vaccine Induces Cross-Reactive Memory Responses
- Ehrlich, H. J.
- Müller M.
- Fritsch, S.
- Zeitlinger M.
- Berezuk, G.
- Löw-Baselli A.
- Van Der Velden, M. V. W.
- Pöllabauer E. M
- Maritsch, F.
- Pavlova, B. G.
- Tambyah, P. A.
- Oh, H. M. L.
- Montomoli E.
- Kistner, O.
- Noel Barrett P.
DOIAbstract
Novel strategies are required to provide rapid vaccine coverage in the event of an influenza pandemic. A phase I/II dose finding/formulation study was performed with a whole-virus H5N1 clade 1 A/Vietnam vaccine (2-dose priming regimen) to evaluate safety and immunogenicity. Seventy-seven of 141 subjects in this study received a booster (12-17 months after priming) with a 7.5-microg dose of a clade 2.1 A/Indonesia vaccine. The prime-boost regimen resulted in antibody responses against clade 1, 2.1, 2.2, and 2.3 viruses that were significantly higher than those after the priming regimen. These findings demonstrate that a prime-boost regimen may alleviate vaccine supply constraints in a pandemic
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