We performed Computational Fluid Dynamics (CFD) modeling, and simulated a people evacuation process from a tunnel in the event of a fire, for evaluating the potentialities of using, as a temporary safety measure, an emergency vehicle equipped with a micronized water system for contrasting the fire growth phase. The structure investigated is a one-way road tunnel with only natural ventilation, and with a length less than 1000 m. The tunnel is assumed at present to be affected by refurbishment works for making it comply with the minimum safety requirements of the European Directive 2004/54/EC. In particular, it is considered that it has not yet been provided with hydrants, and with the sidewalks and the emergency exit which are still under co...