We have set up a Computational Fluid Dynamics (CFD) modeling, and performed a user evacuation model, for evaluating the risk level in one-way road tunnel tube when used for bi-directional traffic in particular circumstances. The simulations were carried out by considering both peak-hour traffic volumes during the day and off-peak hours overnight. The investigated one-way tube is ventilated by natural ventilation only, and has a length of less than 1000 m. With reference to the worst environmental conditions, which are downstream of the fire due to the direction of natural ventilation, the consequences on escaping users, caused by different types of burning vehicles located in various longitudinal positions along the tube, are shown. The res...