Organocatalytic multicomponent synthesis of enantioenriched polycyclic 1,2,3,4-tetrahydro-pyridines: key substrate selection enabling regio-and stereoselectivities †

International audienceWe have developed the first multicomponent synthesis of enantioenriched polycyclic 1,2,3,4-tetrahydropyridines bearing three contiguous stereogenic centers under iminium activation. The key to the success of this reaction was the use of polyfunctional substrates including 2-aminophenols and scarcely used β-ketoamides triggering a thermodynamically controlled regio- and diastereoselective sequence