Add to ORKGMitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that is overexpressed in many cancers, including breast cancer. MKP1 expression is inducible in radiation-treated breast cancer cells, and correlates with human epidermal growth factor receptor 2 (ERBB2, HER2) expression. The role of MKP1 in therapy resistance suggests that targeting MKP1 in HER2-positive breast tumors may significantly enhance the efficacy of anti-HER2 and other anticancer therapies
The MKPs (mitogen-activated protein kinase phosphatases) are a family of at least ten DUSPs (dual-sp...
Mitogen-activated protein kinase (MAPK) cascades regulate diverse cellular functions including proli...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that ...
The MAPK phosphatase MKP1 (DUSP1) is overexpressed in many human cancers, including chemoresistant a...
Drug resistance is a major obstacle in cancer treatment cytotoxic, or targeted therapeutics. Being a...
MAPK phosphatase-1 (MKP-1) is overexpressed during malignant transformation of the breast in many pa...
BACKGROUND: MKP-1 dephosphorylates and inactivates MAPKs, whose constitutive activations have been a...
Doxorubicin (Dox) has limited efficiency in breast cancer (BC) due to drug-acquired resistance. The ...
The mitogen-activated protein kinase (MAPK) phosphatase- 1 (MKP-1) belongs to the MAPK cascades whic...
© 2015 Taylor and Francis Group, LLC. Mitogen activated protein kinase phosphatase-1 (MKP-1) has eme...
There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regul...
Understanding the mechanisms of platinum compound resistance, including cisplatin resistance, has im...
The human epidermal growth factor receptor 2 (HER2) is overexpressed and/or amplified in 15-20% of b...
Antiestrogen resistance is a major clinical problem in the treatment of breast cancer. Altered growt...
The MKPs (mitogen-activated protein kinase phosphatases) are a family of at least ten DUSPs (dual-sp...
Mitogen-activated protein kinase (MAPK) cascades regulate diverse cellular functions including proli...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...
Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that ...
The MAPK phosphatase MKP1 (DUSP1) is overexpressed in many human cancers, including chemoresistant a...
Drug resistance is a major obstacle in cancer treatment cytotoxic, or targeted therapeutics. Being a...
MAPK phosphatase-1 (MKP-1) is overexpressed during malignant transformation of the breast in many pa...
BACKGROUND: MKP-1 dephosphorylates and inactivates MAPKs, whose constitutive activations have been a...
Doxorubicin (Dox) has limited efficiency in breast cancer (BC) due to drug-acquired resistance. The ...
The mitogen-activated protein kinase (MAPK) phosphatase- 1 (MKP-1) belongs to the MAPK cascades whic...
© 2015 Taylor and Francis Group, LLC. Mitogen activated protein kinase phosphatase-1 (MKP-1) has eme...
There are ten mitogen-activated protein kinase (MAPK) phosphatases (MKPs) that act as negative regul...
Understanding the mechanisms of platinum compound resistance, including cisplatin resistance, has im...
The human epidermal growth factor receptor 2 (HER2) is overexpressed and/or amplified in 15-20% of b...
Antiestrogen resistance is a major clinical problem in the treatment of breast cancer. Altered growt...
The MKPs (mitogen-activated protein kinase phosphatases) are a family of at least ten DUSPs (dual-sp...
Mitogen-activated protein kinase (MAPK) cascades regulate diverse cellular functions including proli...
This is an open-access article distributed under the terms of the Creative Commons Attribution Licen...