Add to ORKGDrug resistance is a major obstacle in cancer treatment cytotoxic, or targeted therapeutics. Being an antiapoptot cancer cells, MKP1 phosphatase might be targeted for ove bitor-ors t PI-3 is at oma c (comb %, P ressio n tho ics, 5 ta sho impli prov Introdu Drug r could be treatmen biologica tification standing insights approach MKP1 1, dual-s tified re chemoth ast can-nt with yclines clitaxel; cer cells MKP-1 ed lung cance of rexpres-ast can-cer, and effect is pression 11). ant part horylat-poptoic sion in cancer cells increased apoptosis (12, 14). Among apoptotic action. Inducible MKP1 expression blocked is (17), whereas iates JNK activa-restingly, MKP-
Modulation of multidrug resistance (MDR) has been extensively studied in vitro and in vivo. However,...
Inhibitors of the proteasome, a multicatalytic proteinase com-plex responsible for intracellular pro...
Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD+ biosynthesis from n...
Drug resistance is a major obstacle in cancer treatment cytotoxic, or targeted therapeutics. Being a...
Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that ...
Mitogen-activated protein kinase phosphatase (MKP)-1 is a dual-specificity phosphatase that negative...
The adenoviral gene E1a is known to enhance the antitumor effect of cisplatin, one of the cornerston...
MAPK phosphatase-1 (MKP-1) is overexpressed during malignant transformation of the breast in many pa...
Several oncogenes involved in prostate carcinogenesis activate mitogen- activated protein (MAP) kina...
Reverting cancer drug resistance to chemotherapy and molecular targeted therapies is one of the prin...
Understanding the mechanisms of platinum compound resistance, including cisplatin resistance, has im...
Most anticancer agents mediate their effects through common pathways which induce apoptosis or in so...
The ability of tumor cells to evade apoptosis is established as one of the hallmarks of cancer. The ...
© 2015 Taylor and Francis Group, LLC. Mitogen activated protein kinase phosphatase-1 (MKP-1) has eme...
The concept of protein kinase inhibition starts from the groundbreaking research on the role of thes...
Modulation of multidrug resistance (MDR) has been extensively studied in vitro and in vivo. However,...
Inhibitors of the proteasome, a multicatalytic proteinase com-plex responsible for intracellular pro...
Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD+ biosynthesis from n...
Drug resistance is a major obstacle in cancer treatment cytotoxic, or targeted therapeutics. Being a...
Mitogen-activated protein kinase phosphatase 1 (MKP1 or DUSP1) is an antiapoptotic phosphatase that ...
Mitogen-activated protein kinase phosphatase (MKP)-1 is a dual-specificity phosphatase that negative...
The adenoviral gene E1a is known to enhance the antitumor effect of cisplatin, one of the cornerston...
MAPK phosphatase-1 (MKP-1) is overexpressed during malignant transformation of the breast in many pa...
Several oncogenes involved in prostate carcinogenesis activate mitogen- activated protein (MAP) kina...
Reverting cancer drug resistance to chemotherapy and molecular targeted therapies is one of the prin...
Understanding the mechanisms of platinum compound resistance, including cisplatin resistance, has im...
Most anticancer agents mediate their effects through common pathways which induce apoptosis or in so...
The ability of tumor cells to evade apoptosis is established as one of the hallmarks of cancer. The ...
© 2015 Taylor and Francis Group, LLC. Mitogen activated protein kinase phosphatase-1 (MKP-1) has eme...
The concept of protein kinase inhibition starts from the groundbreaking research on the role of thes...
Modulation of multidrug resistance (MDR) has been extensively studied in vitro and in vivo. However,...
Inhibitors of the proteasome, a multicatalytic proteinase com-plex responsible for intracellular pro...
Nicotinamide phosphoribosyltransferase (NAMPT), the rate-limiting enzyme in NAD+ biosynthesis from n...